MovDisordV3, Main, Exploration, bibRecord, 001198

Basal Ganglia-Premotor Dysfunction during Movement Imagination in Writer's Cramp

Identifieur interne : 001198 ( Main/Exploration ); précédent : 001197; suivant : 001199

Basal Ganglia-Premotor Dysfunction during Movement Imagination in Writer's Cramp

Auteurs : Florian Castrop [Allemagne] ; Christian Dresel [Allemagne] ; Andreas Hennenlotter [Allemagne] ; Claus Zimmer [Allemagne] ; Bernhard Haslinger [Allemagne]

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:12-0393085

Descripteurs français

Pascal (Inist)
- Crampe écrivain, Dystonie, Pathologie du système nerveux, Noyau gris central, Trouble fonctionnel, Imagination, Imagerie RMN.

English descriptors

KwdEn :
- Basal ganglion, Dysfunction, Dystonia, Imagination, Nervous system diseases, Nuclear magnetic resonance imaging, Writer cramp.

Abstract

The pathophysiology of idiopathic focal hand dystonia (writer's cramp) is characterized by deficient inhibitory basal ganglia function and altered cortical sensorimotor processing. To explore if this is already a primary finding in dystonia for internal movement simulation independent of dystonic motor output or abnormal sensory input, we investigated the neural correlates of movement imagination and observation in patients with writer's cramp. Event-related fMRI was applied during kinesthetic motor imagery of drawing simple geometric figures (imagination task) and passively observing videos of hands drawing identical figures (observation task). Compared with healthy controls, patients with writer's cramp showed deficient activation of the left primary sensorimotor cortex, mesial and left dorsal premotor cortex, bilateral putamen, and bilateral thalamus during motor imagery. No significant signal differences between both groups were found during the observation task. We conclude that internal movement simulation and planning as tested during imagination of hand movements appear to be dysfunctional in patients with writer's cramp, whereas visual signal processing and observation-induced activation are unaffected. Deficient basal ganglia-premotor activation could be a correlate of impaired basal ganglia inhibition and focusing during the selection of motor programs in dystonia. This finding seems to be an intrinsic deficit, as it is found during motor imagery in the absence of dystonic symptoms.

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">The pathophysiology of idiopathic focal hand dystonia (writer's cramp) is characterized by deficient inhibitory basal ganglia function and altered cortical sensorimotor processing. To explore if this is already a primary finding in dystonia for internal movement simulation independent of dystonic motor output or abnormal sensory input, we investigated the neural correlates of movement imagination and observation in patients with writer's cramp. Event-related fMRI was applied during kinesthetic motor imagery of drawing simple geometric figures (imagination task) and passively observing videos of hands drawing identical figures (observation task). Compared with healthy controls, patients with writer's cramp showed deficient activation of the left primary sensorimotor cortex, mesial and left dorsal premotor cortex, bilateral putamen, and bilateral thalamus during motor imagery. No significant signal differences between both groups were found during the observation task. We conclude that internal movement simulation and planning as tested during imagination of hand movements appear to be dysfunctional in patients with writer's cramp, whereas visual signal processing and observation-induced activation are unaffected. Deficient basal ganglia-premotor activation could be a correlate of impaired basal ganglia inhibition and focusing during the selection of motor programs in dystonia. This finding seems to be an intrinsic deficit, as it is found during motor imagery in the absence of dystonic symptoms.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Basal Ganglia-Premotor Dysfunction during Movement Imagination in Writer's Cramp

Basal Ganglia-Premotor Dysfunction during Movement Imagination in Writer's Cramp

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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